线粒体功能障碍在多种神经系统疾病中扮演关键角色。在蛛网膜下腔出血中，缺血缺氧导致线粒体功能受损，释放大量活性氧和炎症介质，激活凋亡通路，而线粒体质量控制机制是潜在治疗靶点。在亨廷顿病中，CAG重复扩增导致线粒体能量代谢障碍、生物发生异常、运输受阻及钙稳态失调。脊髓损伤后，线粒体稳态破坏影响ATP产生，阻碍轴突再生与修复，恢复线粒体功能可促进神经功能恢复。在阿尔茨海默病中，线粒体功能障碍与脑葡萄糖代谢降低密切相关，葡萄糖缺乏导致O-GlcNAcylation水平改变，进而影响线粒体功能。
线粒体网络动力学缺陷、氧化磷酸化异常及活性氧过度产生是这些疾病的共同病理机制，针对线粒体生物发生、动力学平衡、运输功能及代谢异常的干预策略为神经系统疾病治疗提供了新方向。
因此，特精选本刊2023-2024年发表的线粒体功能障碍在神经系统疾病中的作用研究的热点综述文章5篇，供读者参阅。
(1) Mitochondrial dysfunction and quality control lie at the heart of subarachnoid hemorrhage
线粒体功能障碍和质量控制是蛛网膜下腔出血的核心所在
展开剩余82%引用本文：
Zhang J, Zhu Q, Wang J, Peng Z, Zhuang Z, Hang C, Li W. Mitochondrial dysfunction and quality control lie at the heart of subarachnoid hemorrhage. Neural Regen Res. 2024;19(4):825-832.
正文链接:
https://journals.lww.com/nrronline/fulltext/2024/04000/mitochondrial_dysfunction_and_quality_control_lie.27.aspx
(2) Crosslink between mutations in mitochondrial genes and brain disorders: implications for mitochondrial-targeted therapeutic interventions
线粒体基因突变与脑部疾病之间的交叉联系：线粒体靶向治疗干预的意义
引用本文：
Kalra J. Crosslink between mutations in mitochondrial genes and brain disorders: implications for mitochondrial-targeted therapeutic interventions. Neural Regen Res. 2023;18(1):94-101.
正文链接:
https://journals.lww.com/nrronline/fulltext/2023/01000/crosslink_between_mutations_in_mitochondrial_genes.14.aspx
(3) Mitochondria in Huntington's disease: implications in pathogenesis and mitochondrial-targeted therapeutic strategies
亨廷顿氏病中的线粒体：对发病机制和线粒体靶向治疗策略的影响
引用本文：
Jurcau A, Jurcau CM. Mitochondria in Huntington's disease: implications in pathogenesis and mitochondrial-targeted therapeutic strategies. Neural Regen Res. 2023;18(7):1472-1477.
正文链接:
https://journals.lww.com/nrronline/fulltext/2023/07000/mitochondria_in_huntington_s_disease__implications.12.aspx
(4) Mitochondrial dysfunction as a target in spinal cord injury: intimate correlation between pathological processes and therapeutic approaches
脊髓损伤中线粒体功能障碍作为靶点：病理过程与治疗策略的密切关联
引用本文：
Schmidt J, Quintá HR. Mitochondrial dysfunction as a target in spinal cord injury: intimate correlation between pathological processes and therapeutic approaches. Neural Regen Res. 2023;18(10):2161-2166.
正文链接:
https://journals.lww.com/nrronline/fulltext/2023/10000/mitochondrial_dysfunction_as_a_target_in_spinal.10.aspx
(5) Altered O-GlcNAcylation and mitochondrial dysfunction, a molecular link between brain glucose dysregulation and sporadic Alzheimer's disease
O-GlcNAcylation改变与线粒体功能障碍——脑葡萄糖调节失常与散发性阿尔茨海默病间的分子关联
引用本文：
Huang CW, Rust NC, Wu HF, Hart GW. Altered O-GlcNAcylation and mitochondrial dysfunction, a molecular link between brain glucose dysregulation and sporadic Alzheimer's disease. Neural Regen Res. 2023;18(4):779-783.
正文链接:
https://journals.lww.com/nrronline/fulltext/2023/04000/altered_o_glcnacylation_and_mitochondrial.14.aspx
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